As per the studies done by the researchers, it has been learnt that the unexpected link between the hair and skin pigmentation disorder might cause implications for vitiligo and malignant melanoma. The researcher Richard A. Spritz, MD of the University of Colorado is of the view that the generalized vitiligo in Caucasians of European descent’s research of the genome wide association largely hemmed the associations with immune-related genes done in the past.
Richard then uttered and explained in an interview that the linkup with the TYR genetic locus (P=1.60×10-18) emerged as a big surprise.
This gene, as per the studies, instructs the tyrosinase, which is the key enzyme in melanocytes which creates the melanin and happens to be the chief target of the autoimmunity in generalized vitiligo. This gives in turn the significant view of the pathogenesis of vitiligo and points out the targets to be treated for the disease that catches around 0.5% to 1% of the population.
Richard then uttered and explained in an interview that the linkup with the TYR genetic locus (P=1.60×10-18) emerged as a big surprise.
This gene, as per the studies, instructs the tyrosinase, which is the key enzyme in melanocytes which creates the melanin and happens to be the chief target of the autoimmunity in generalized vitiligo. This gives in turn the significant view of the pathogenesis of vitiligo and points out the targets to be treated for the disease that catches around 0.5% to 1% of the population.
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